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Flumethasone Home您现在的位置:HOME >> PRODUCTS >> sterides Active ingredient

Flumethasone

所属类别:sterides Active ingredient 点击次数:502次 发布时间:2017-04-12

Flumethasone
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 Flumethasone Basic Info.
CAS: 2135-17-3 
MF: C22H28F2O5 
MW: 410.45 
EINECS: 218-370-9 
mp: 237-240°C 
storage temp:2-8°C
Purity: 99%
Flumetasone is a corticosteroid for topical use.  It is available in combination with clioquinol, for the treatment of otitis externa and otomycosis. It is usually formulated as the pivalic acid ester prodrug flumetasone pivalate.
 
Flumethasone Function:
Flumethasone is a glucocorticoid receptor agonist. This complex binds to the nucleus causing a variety of genetic activation and repressions. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Flumethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin.

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