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Buy Sarms SR9011 powder Home您现在的位置:HOME >> PRODUCTS >> SARMS

Buy Sarms SR9011 powder

所属类别:SARMS 点击次数:545次 发布时间:2017-07-07

详情
 SR9011  Basic Info.
CAS No.: 1379686-30-2
Molecular formular: C20H24ClN3O4S
Molecular Weight: 437.94
Appearance: White powder
Purity: 99%
Application: SR9011 increase exercise endurance and loss weight.
Usage:reduce mass fat
Packing:1kg/foil bag
 
 SR9011Description:
SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates.
SR9011 is recommended for use in peroxide cured coatings, sealants, and PVC-based plastisols. 


SR9011 as an agonist of REV-ERB with IC50 = 790 nM for REV-ERBα and IC50 = 560 nM for REV-ERBβ. IC50 value: 790 nM (Rev-ErbBα), 560 nM (Rev-ErbBβ) Target: Rev-ErbB in vitro: SR9011 dose-dependently increases the REV-ERB-dependent repressor activity assessed in HEK293 cells expressing a chimeric Gal4 DNA Binding Domain (DBD) - REV-ERB ligand binding domain (LBD) α or β and a Gal4-responsive luciferase reporter.SR9011 and SR9009 potently and efficaciously suppresses transcription in a cotransfection assay using full-length REV-ERBα along with a luciferase reporter driven by the Bmal1 promoter (SR9011 IC50=620 nM). SR9011 suppresses the expression of BMAL1 mRNA in HepG2 cells in a REV-ERBα/β-dependent manner. in vivo: SR9011 are synthetic REV-ERB agonists with activity. SR9011 also inhibits the activity of the SCN clock, with reversible inhibition of circadian oscillations in SCN explants cultured from the Per2:luc reporter mouse.


 

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