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Buy Sarms GW0742 powder

所属类别:SARMS 点击次数:331次 发布时间:2017-07-07

GW0742
详情
Name: GW0742 
CAS: 317318-84-6 
Chemical Formula: C21H17F4NO3S2 
Exact Mass: 471.0586 
Molecular Weight: 471.4846 
 
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
Harmonized System Code: 293490

We identified proapoptotic transcriptional changes, including the up-regulation of proapoptotic Bax and down-regulation of anti-apoptotic Bcl-2, using Western blot assay and by immunohistochemical staining. We report in the present study for the first time that treatment with GW0742 in acute lung injury documents features of apoptotic cell death after CAR administration, suggesting that protection from apoptosis may be a prerequisite for anti-inflammatory approaches. In particular, we demonstrated that treatment with GW0742 lowers the signal for Bax in the treated group when compared with lung sections obtained from CAR-treated mice, whereas on the contrary, the signal is highly expressed for Bcl-2 in GW0742-treated mice than in CAR-treated mice. This demonstrates that GW0742, by inhibiting NF-κB, prevents the loss of the antiapoptotic pathway and reduces the proapoptotic pathway activation with a mechanism still yet to be discovered. Taken together, the results of the present study enhance our understanding of the role of PPAR-β/δ in the pathophysiology of acute inflammation. Our results imply that PPAR-β/δ agonists such as GW0742 may be useful in the therapy of inflammation.


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