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Pentostatin(Nipent,Deoxycoformycin) Home您现在的位置:HOME >> PRODUCTS >> Medicine Active ingredient


所属类别:Medicine Active ingredient 点击次数:534次 发布时间:2017-04-13

Product Name: Pentostatin 
Other Names: PENTOSTATIN;(r)-3-(2-deoxy-beta-d-erythro-pento-furanosyl)-3,6,7,8-tetrahydroimidazo[4,5-d;(r)-3-(2-deoxy-beta-d-pentofuranosyl)-3,6,7,8-tetrahydroimidazo(4,5-d)(1,3)d;(r)-deoxycoformycin;(r)-rahydro;2'dcf;2'-deoxycoformycin;ci-825
Model No.: SYT-760
CAS No.: 53910-25-1
Molecular Formula: C11H16N4O4
Molecular Weight: 268.27
Appearance: White Solid
Melting Point: N/A
Purity: 99.6%
Product Description:
Pentostatin is an antibiotic chemotherapy drug. It is most commonly used to treat hairy cell leukemia, a form of cancer in which the patient has too many abnormal B lymphocytes. Another frequent use is to treat chronic lymphocytic leukemia. Pentostatin may also be administered to patients with lymphoma or other kinds of leukemia. It is marketed under the brand name Nipent®.
The drug attempts to stop or impede the production of cancerous cells by slowing the production of DNA. It does this by blocking the production of an element called ribonucleotide reductase. This helps to prevent cell division, which is more active in cancerous cells. While the drug does cause DNA damage, it does not tend to have as strong an effect on the development of normal cells as they do not need to divide as frequently.
1. Pentostatin is a potent antitumour antibiotic isolated from a Streptomyces species. Pentostatin is a potent inhibitor of adenine deaminase and has been used therapeutically as an antitumour agent.
2. An adenosine deaminase inhibitor used as an anti-cancer therapeutic drug. Shown to be effective in the treatment of hairy cell leukemia as well as having use in the treatment of other types of cancer such as chronic lymphocytic leukemia.
Patients who are undergoing pentostatin treatment will often have a decrease in blood cells. For this reason, many doctors will test blood cell levels before, during and after the drug therapy. Some drugs may also increase the risk of taking pentostatin, including aspirin, allopurinal,, and vidarabine. Women are typically advised not to get pregnant while undergoing treatment. Receiving vaccinations of any kind while taking the drug may also increase the risk of an adverse reaction.

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