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Intedanib Home您现在的位置:HOME >> PRODUCTS >> Inhibitors

Intedanib

所属类别:Inhibitors 点击次数:472次 发布时间:2017-04-13

Intedanib
详情
 Intedanib Basic Info.
 
Synonyms:Intedanib;Vargatef;Nintedanib;Nintedanib (BIBF 1120);Nintedanib/Intedanib/Vargatef;Intedanib Vargatef;methyl (3Z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylate Nintedanib (BIBF 1120);Vargatef (nintedanib)
CAS:656247-17-5
MF:C31H33N5O4
MW:539.62482
Mol File:656247-17-5.mol
Assay:99%
Appearance:White crystalline powder
Product Categories:Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors
 
Usage:It is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases; an indolinone as triple angiokinase inhibitors.
 
Nintedanib Application
 
• Nintedanib, marketed under the brand names Ofev and Vargatef, is a medication used for the treatment of idiopathic pulmonary fibrosis (IPF) and along with other medications for some types of non-small-cell lung cancer.Common side effects include abdominal pain, vomiting, and diarrhea. It is a small molecule tyrosine-kinase inhibitor, targeting vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet derived growth factor receptor (PDGFR).It was developed by Boehringer Ingelheim. At an assumed cost of 39,300 pounds per year it does not appear to be cost effective for IPF in the United Kingdom.
• Nintedanib is also called by its brand name Vargatef. It is a treatment for a type of non small cell lung cancer called adenocarcinoma.Nintedanib is for people who have already had one type of chemotherapy and whose cancer has grown back or has spread. You have it with a type of chemotherapy called docetaxel.You usually keep taking it for as long as it is working unless side effects get too bad.You may have nintedanib as part of clinical trials for other types of cancer.
 
 
Nintedanib Function:
 
Nintedanib is a cancer growth blocker. It works by blocking particular proteins called protein kinases in cancer cells. The protein kinases encourage the cancer to grow. Nintedanib blocks a number of these proteins and is called a multi kinase inhibitor. It also stops the cancer cells growing their own blood vessels, which the cells need to be able to grow.Nintedanib may shrink the cancer or stop it growing for a time.
 

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