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Buy MMAF powder 10mg 100mg 1g price Home您现在的位置:HOME >> PRODUCTS >> Inhibitors

Buy MMAF powder 10mg 100mg 1g price

所属类别:Inhibitors 点击次数:135次 发布时间:2017-04-13

MMAF powder
详情
 MMAF Basic Info.
CAS:1415246-68-2
MW:768.42
MF:C39H66CIN5O8
DMSO: ≤ 27 mg/mL
Monomethylauristatin F Hcl(MMAF Hcl) is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin; lower cytotoxic activity than MMAE; antibody drug cytotoxin.
IC50 value:
Target: tubulin; ADCs cytotoxin
Monomethylauristatin F Hcl(MMAF Hcl) is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin; lower cytotoxic activity than MMAE; antibody drug cytotoxin.
 
MMAF is a new auristatin derivative with a charged C-terminal phenylalanine that attenuates its cytotoxic activity compared to its uncharged counterpart, Monomethyl auristatin E (MMAE). Because of MMAF is highly toxic, it cannot be used as a drug itself.  MMAF induces potent antitumor effects when conjugated via protease cleavable linkers to a monoclonal antibody targeting internalizing, tumor-specific cell surface antigens. The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the anti-mitotic mechanism.

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