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AZD6244/Selumetinib Home您现在的位置:HOME >> PRODUCTS >> Inhibitors

AZD6244/Selumetinib

所属类别:Inhibitors 点击次数:897次 发布时间:2017-04-13

AZD6244/Selumetinib
详情
 AZD6244/Selumetinib Basic Info.
 
CAS Number: 606143-52-6
Name: 1H-benzimidazole-6-carboxamide, 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-
Superlist Name: AZD 6244
Formula: C17H15BrClFN4O3
Molecular Weight: 457.68
Synonyms: AZD 6244; 5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide; 
Density: 1.692 g/cm3
 
 
Application:
AZD6244 is effective in inhibiting tumor growth at all doses tested. The time to the tumor growth end point was 36 days for the two highest dose groups compared with 18 days for the vehicle control group. Tumor growth after 11 days of dosing was inhibited by 55% at the low dose of 10 mg/kg and by 70% at the high dose of 100 mg/kg. Recovery of tumor growth was observed after cessation of AZD6244 administration. Tumor regrowth was significantly delayed in the 100 mg/kg dose group.

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