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AP26113 Home您现在的位置:HOME >> PRODUCTS >> Inhibitors

AP26113

所属类别:Inhibitors 点击次数:443次 发布时间:2017-04-13

AP26113
详情
 AP26113 Basic Info.
CAS:1197958-12-5
Assay:99%
MF:C26H34ClN6O2P
MW529.01
Usage:AP26113 is a kind of effective ALK inhibitors for positive ALK mutations in non-small cell lung cancer.
 
 
AP26113 is an effective ALK inhibitors, IC50 was 0.62 nM, can overcome due to the effect of Crizotinib resistance of the mediated L1196M mutations. AP26113 highly effective on the sensitive and resistant H3122 cells, reduce the cell growth, inhibition of ALK, phosphate and induction of apoptosis, this effect is dose dependent. Applied to H3122 AP26113 and H3122 CR cells, reduce p - ALK, IC50 were 7.4 and 16.8 nM. AP26113 role in expressing wild-type and mutant EML4 - ALK Ba/F3 cells, reduce the cell number, 24 nM to 10 nM and IC50 respectively.

上一产品: API Linifanib (ABT-869)
下一产品: AZD-9291
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