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Triptorelin Home您现在的位置:HOME >> PRODUCTS >> Peptides

Triptorelin

所属类别:Peptides 点击次数:287次 发布时间:2017-04-12

Triptorelin
详情
 Triptorelin is a gonadotropin releasing hormone (GnRH) agonist that is a potent inhibitor of the synthesis of testosterone (in men) and estrogen (in women) and is used to treat advanced prostate cancer.  It is a man-made form of a hormone that regulates many processes in the body. Triptorelin overstimulates the body's own production of certain hormones, which causes that production to shut down temporarily.
 
Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-PRO-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction. Triptorelin is marketed under the brand names Decapeptyl (Ipsen) and Diphereline and Gonapeptyl (Ferring Pharmaceuticals).
 
Triptorelin Basic info:
Triptorelin Acetate
Purity (HPLC): 99.3.0% min.
Appearance: White powder
Molecular Formula: C64H82N18O13
Molecular Weight: 1311.46
Single Impurity (HPLC): 1.0%max
Amino Acid Composition: ±10% of theoretical
Peptide Content (N%): ≥88.0% 
Water Content(Karl Fischer): ≤6.0%
Acetate Content (HPIC): ≤15.0%
MS(ESI): Consistent
Mass Balance: 95.0~105.0%
Specific Rotation (20/D): -65.0~-75.0°(c=0.5 1%HAc)
 
Triptorelin Product Description:
 
Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts. 
 
Triptorelin raises testosterone levels by causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction.
 
Triptorelin is marketed under the brand names Decapeptyl (Ipsen) and Diphereline and Gonapeptyl (Ferring Pharmaceuticals). In the United States, it is sold by Watson as Trelstar.In Iran Triptorelin is marketed under the brand name Variopeptyl (Varian Darou Pajooh).
 
In India, Dr. Reddy's Laboratories has launched recently Triptorelin under the brand name "Pamorelin LA". During the treatment of prostate cancer it does cause a surge of testosterone (an initial uplevel of testosterone levels), known as a flare effect. In men a reduction of serum testosterone levels into the range normally seen after surgical castration occurs approximately two to four weeks after initiation of therapy. 
 
Triptorelin raises testosterone levels by causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction.
 
Triptorelin Application:
 
Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction. Triptorelin is marketed under the brand names Decapeptyl (Ipsen) and Diphereline and Gonapeptyl . In the United States, it is sold by Watson as Trelstar.In Iran Triptorelin is marketed under the brand name Variopeptyl (Varian Darou Pajooh). In India, Dr. Reddy's Laboratories has launched recently Triptorelin under the brand name "Pamorelin LA". In men a reduction of serum levels into the range normally seen after surgical castration occurs approximately two to four weeks after initiation of therapy.

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