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pentadecapeptide BPC 157

所属类别:Peptides 点击次数:941次 发布时间:2017-04-12

pentadecapeptide BPC 157
BPC 157 Function:
BPC 157, also known as BPC-157, BPC 15, or Booly Protection Compound 15, is a 15 amnio acid chain that possesses a molecular mass of 1419.53552.  It has a molecular formula of C62H98N16O22. 
The Functionality of BPC 157
According to scientific study that has been conducted on animal test subjects, BPC 157 has been shown to possess anti-ulcer peptidgeric properties. What this means is, it has shown an ability to provide a means of regulatory control over the digestive tract's overall functionality.  It has been determined that this function protects the endothelium and promotes the process of angiogenesis.  These particular functions can be related to several other functions that have been connected to the peptide, including wound healing and blood flow regulation throughout an animal test subject's gastro-intestinal tract.  Additionally, BPC 157's functionality has been shown to be linked to anti-inflammatory properties.
BPC 157 and the Gastro-Intestinal Tract
Because of the way in which BPC 157's inherent mechanics operate in conjunction with an animal test subject's digestive tract, scientific studies have produced several hypothetical ways in which the peptide could provide aid regarding specific functions pertaining to the gastro-intestinal tract. For instance, it is thought that the peptide's wound-healing and anti-inflammatory properties could provide aid in the treatment to various inflammatory bowel diseases such as Chron's disease and ulcerative colitis.  The anti-inflammatory properties have also allowed the peptide to be linked to conceivable quelling the effects of periodontitis around the teeth.
Purely for Scientific Research
Despite the fact that there has been plenty of research on BPC 157 in relation to how it functions and the benefits that can be derived from such functionality, it should be emphasized that the peptide is still just intended for scientific study at this point in time.  Because of this, any findings or observations relating to BPC 157's overall functionality, mechanics, benefits, should exclusively be the product of study performed in a strictly contained environment.
BPC 157 Basic Info.
Alias: Booly Protection Compound 15, Pentadecapeptide, BPC 157 
CAS: 137525-51-0 
Sequence: Gly-Glu-Pro-Pro-Pro-Gly- Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val 
MF: C62H98N16O22 
MW: 1419.53552 
Purity: 99% 
Specification: 2mg/vial 
Appearance: White Lyophilized Powder 
Place of Origin: China 
Standard: USP 
Certification: SGS 
Method of Analysis: HPLC 
Storage: Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18° C. Upon reconstitution of the peptide it should be stored at 4° C between 2-21 days and for future use below -18° C
BPC 157 Description :
BPC 157 has a strong anti-inflammatory activity in both acute and chronic inflammation models. In fact, preliminary results in clinical trials suggest that BPC 157 may become an important therapeutic tool for the treatment of inflammatory bowel disease. BPC 157 was shown to accelerate wound healing and to have a marked angiogenic effect. In addition, it significantly facilitates the healing of bone fracture in rats. This peptide also exhibits an osteogenic effect significantly improving the healing of segmental bone defect. BPC 157 accelerates the healing of transected rat Achilles tendon and transected rat quadriceps muscle.
Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice. Experimentally it has been demonstrated to accelerate the healing of many different wounds, including transected rat Achilles tendon. 
This study was designed to investigate the potential mechanism of BPC 157 to enhance healing of injured tendon. The outgrowth of tendon fibroblasts from tendon explants cultured with or without BPC 157 was examined. Results showed that BPC 157 significantly accelerated the outgrowth of tendon explants. Cell proliferation of cultured tendon fibroblasts derived from rat Achilles tendon was not directly affected by BPC 157 as evaluated by MTT assay. 
However, the survival of BPC 157-treated cells was significantly increased under the H(2)O(2) stress. BPC 157 markedly increased the in vitro migration of tendon fibroblasts in a dose-dependent manner as revealed by transwell filter migration assay. BPC 157 also dose dependently accelerated the spreading of tendon fibroblasts on culture dishes. The F-actin formation as detected by FITC-phalloidin staining was induced in BPC 157-treated fibroblasts. The protein expression and activation of FAK and paxillin were determined by Western blot analysis, and the phosphorylation levels of both FAK and paxillin were dose dependently increased by BPC 157 while the total amounts of protein was unaltered.
In conclusion, BPC 157 promotes the ex vivo outgrowth of tendon fibroblasts from tendon explants, cell survival under stress, and the in vitro migration of tendon fibroblasts, which is likely mediated by the activation of the FAK-paxillin pathway.

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