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Delta sleep-inducing peptide(DSIP)

所属类别:Peptides 点击次数:424次 发布时间:2017-04-12

Delta sleep-inducing peptide(DSIP)
详情
 Discovery
Delta sleep-inducing peptide was first discovered in 1974 by the Swiss Schoenenberger-Monnier group who isolated it from the cerebral venous blood of rabbits in an induced state of sleep. It was primarily believed to be involved in sleep regulation due to its apparent ability to induceslow-wave sleep in rabbits, but studies on the subject have been contradictory.
Delta-sleep-inducing peptide (DSIP)-like material has been found in human breast milk
 
 
Delta sleep-inducing peptide(DSIP) Basic Info.
 
Sequence:r-l-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Specification:  2mg/vial;
CAS No: 62568-57-4
Formula: C35H48N10O15
Molecular Weight: 848.81
Purity: 99.0%min
 
DSIP  Function
Many roles for DSIP have been suggested following research carried out using peptide analogues with a greater molecular stabilityand through measuring DSIP-like immunological (DSIP-LI) response by injecting DSIPantiserum and antibodies.
Roles in endocrine regulation
Decreases basal corticotropin level and blocks its release.
Stimulates release of luteinizing hormone (LH).
Stimulates release of somatoliberin and somatotrophin secretion and inhibits somatostatin secretion.
 
Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.
 
Delta sleep-inducing peptide was first discovered in 1974 by the Swiss Schoenenberger-Monnier group who isolated it from the cerebral venous blood of rabbits in an induced state of sleep. It was primarily believed to be involved in sleep regulation due to its apparent ability to induce slow-wave sleep in rabbits, but studies on the subject have been contradictory.
 
DSIP is an amphiphilic peptide of molecular weight 850 daltons with the amino acid motif:
N-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-C
 
It has been found in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids. In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). It is abundant in the gut secretory cells and in the pancreas where it co-localises with glucagon.
 
In the brain its action may be mediated by NMDA receptors. In another study Delta sleep-inducing peptide stimulated Acetyltransferase activity through α1 receptors in rats.It is unknown where DSIP is synthesized.
 
DSIP  Applications:
Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.
Many roles for DSIP have been suggested following research carried out using peptide analogues with a greater molecular stability and through measuring DSIP-like immunological (DSIP-LI) response by injecting DSIP antiserum and antibodies.

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